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Animal&Cell Models

Humanized animal models

Humanization of immune checkpoints

Text

B-hCD28/hCD20 mice

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Strain Name	C57BL/6-Cd28^{tm1(CD28)Bcgen} Ms4a1^{tm2(MS4A1)Bcgen}/Bcgen	Common Name	B-hCD28/hCD20 mice
Background	C57BL/6	Catalog number	121253
Related Genes	CD28, CD28 molecule, Tp44; CD20, MS4A1, membrane spanning 4-domains A1, B1, Bp35, CD20, CVID5, LEU-16, MS4A2, S7
NCBI Gene ID	12487,12482

Model validation

Protein expression analysis

Strain specific CD28 expression analysis in homozygous B-hCD28/hCD20 mice by flow cytometry.

Splenocytes were collected from WT and homozygous B-hCD28/hCD20 (H/H;H/H) mice, and analyzed by flow cytometry with species-specific anti-CD28 antibody. Mouse CD28 was detectable in WT mice. Human CD28 was exclusively detectable in homozygous B-hCD28/hCD20 but not WT mice.

Protein expression analysis

Strain specific CD20 expression analysis in homozygous B-hCD28/hCD20 mice by flow cytometry.

Splenocytes were collected from WT and homozygous B-hCD28/hCD20 (H/H;H/H) mice, and analyzed by flow cytometry with species-specific anti-CD20 antibody. Mouse CD20 was detectable in WT mice. Human CD20 was exclusively detectable in homozygous B-hCD28/hCD20 but not WT mice.

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