Efficacy evaluation of cisplatin in syngeneic model
A: Efficacy evaluation of Cisplatin in C57BL/6N mice. Cisplatin inhibited B-hPD-1 LLC1 tumor growth in C57BL/6N mice. Humanized murine lung cancer B-hPD-1 LLC1 cells (2×105) were subcutaneously implanted into C57BL/6N mice (female,8-week-old,n=6).Mice were grouped when tumor volume reached approximately 100 mm3 ,at which time they were treated with Cisplatin. B: Efficacy evaluation of Cisplatin in B-hPD-1 mice. Cisplatin inhibited B-hPD-L1 MC38 tumor growth in B-hPD-1 mice. B-hPD-L1 MC38 cells (5×105) were subcutaneously implanted into B-hPD-1 mice (female,7-week-old,n=6).Mice were grouped when tumor volume reached approximately 100 mm3 ,at which time they were treated with Cisplatin.