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Atherosclerosis model in ApoE KO mice

Establishment of special diet-induced atherosclerosis model in ApoE-/- mice

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(A-B) Atherosclerotic plaques of mice at 12 and 20 weeks.(C-D) Oil Red results of aortic sinus at 12 and 20 weeks. (E) Gross staining of aortic arch at 12 weeks.

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Tissue staining and blood biochemical results in the mouse model of atherosclerosis at 12 weeks (A) H&E results of aortic sinus Increased. (B-C) Immunohistochemistry shows expression of α-SMA and F4/80. (D) ALT, AST, TC, TG, HDL-C and LDL-C levels in serum. Values are expressed as mean ± SEM. **p<0.01, ****p<0.0001.

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