| Strain Name |
C57BL/6-Cd3etm1(CD3E)Bcgen Cd3dtm1(CD3D)Bcgen Cd3gtm1(CD3G)Bcgen Tnfrsf9tm1(TNFRSF9)Bcgen/Bcgen |
Common Name | B-hCD3EDG/h4-1BB mice |
| Background | C57BL/6 | Catalog number | 112646 |
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Aliases |
CD3E, CD3epsilon, IMD18, T3E, TCRE, CD3 epsilon subunit of T-cell receptor complex; CD3D, CD3-DELTA, CD3DELTA, IMD19, T3D, CD3 delta subunit of T-cell receptor complex; CD3G, CD3-GAMMA, CD3GAMMA, IMD17, T3G, CD3 gamma subunit of T-cell receptor complex; TNFRSF9, TNF receptor superfamily member 9,4-1BB, CD137, CDw137, ILA |
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Analysis of lymph node T cell subpopulations by FACS. Leukocytes were isolated from female C57BL/6 and B-hCD3EDG/h4-1BB mice (n=3, 6 week-old). Flow cytometry analysis of the leukocytes was performed to assess T cell subsets. A. Representative FACS plots. Single live CD45+ cells were gated for CD3 T cell population and used for further analysis as indicated here. B. Results of FACS analysis. Percent of CD8+ T cells, CD4+ T cells and Treg cells in homozygous B-hCD3EDG/h4-1BB mice were similar to those in the C57BL/6 mice, demonstrating that introduction of CD3EDG and 4-1BB in place of its mouse counterpart does not change the overall development, differentiation or distribution of these T cell sub types in lymph node. Values are expressed as mean ± SEM.
Analysis of blood leukocytes cell subpopulations in B-hCD3EDG/h4-1BB mice
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