Project background

Il2rg is known as the interleukin receptor common gamma chain, which is an important signaling component of many interleukin receptors, including those of interleukin-2, interleukin-4, interleukin-7 and interleukin-21. Mutations in this gene cause X-linked severe combined immunodeficiency. This rat can be used to support research in many areas including immunology, inflammation research, cancer research, xenograft/transplant host etc.

Homozygous Il2rg^tm1/Bcgen rats demonstrate significantly reduced mature T, B and NK cells in spleen. Markedly diminished T cells, B cells and NK cells are proved in homozygous Il2rg^tm1/Bcgenrats (Figure 1), the same as reported, and similar to the phenotype in homozygous Il2rg knockout mice.

1. Ohbo, K., et al., Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain. Blood, 1996. 87(3): p. 956-67. [PubMed: 8562967]

2. Mashimo, T., et al., Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases. PLoS One, 2010. 5(1): p. e8870. [PubMed: 20111598]

3. Mashimo, T., et al., Generation and characterization of severe combined immunodeficiency rats. Cell Rep, 2012. 2(3): p. 685-94. [PubMed: 22981234]