B-hCD98HC/Rag2 KO mice
| Strain Name | C57BL/6N-Slc3a2tm1(SLC3A2)Rag2tm1/Bcgen | Common Name | B-hCD98HC/Rag2 KO mice |
| Background | C57BL/6N | Catalog number | 112326 |
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Related Genes |
SLC3A2, 4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE, CD98 heavy chain; RAG2, RAG-2, recombination activating 2
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Model validation
Protein expression analysis in brain endothelial cells
Strain specific CD98 expression analysis in homozygous B-hCD98/Rag2 KO mice by flow cytometry. Brain were collected from wild type (WT) mice (+/+) and homozygous B-hCD98HC/Rag2 KO mice (H/H;-/-), and analyzed by flow cytometry with species-specific anti-CD98 antibody after trypsin digestion. Mouse CD98 was detectable in WT mice (+/+). Human CD98 was exclusively detectable in homozygous B-hCD98HC/Rag2 KO mice (H/H;-/-) but not in WT mice (+/+).
Strain specific CD98 expression analysis in homozygous B-hCD98HC/Rag2 KO mice by flow cytometry. Splenocytes were collected from wild type (WT) mice (+/+) and homozygous B-hCD98HC/Rag2 KO mice (H/H;-/-), and analyzed by flow cytometry with species-specific anti-CD98 antibody. Mouse CD98 was detectable in WT mice (+/+) and human CD98 was not detectable in WT mice (+/+). There were no T cells in homozygous B-hCD98HC/Rag2 KO mice.
Strain specific CD98 expression analysis in homozygous B-hCD98HC/Rag2 KO mice by flow cytometry. Splenocytes were collected from wild type (WT) mice (+/+) and homozygous B-hCD98HC/Rag2 KO mice (H/H;-/-), and analyzed by flow cytometry with species-specific anti-CD98 antibody. Mouse CD98 was detectable in WT mice (+/+) and human CD98 was not detectable in WT mice (+/+). There were no B cells in homozygous B-hCD98HC/Rag2 KO mice.
Strain specific CD98 expression analysis in homozygous B-hCD98HC/Rag2 KO mice by flow cytometry. Splenocytes were collected from wild type (WT) mice (+/+) and homozygous B-hCD98HC/Rag2 KO mice (H/H;-/-), and analyzed by flow cytometry with species-specific anti-CD98 antibody. Mouse CD98 was detectable in WT mice (+/+). Human CD98 was exclusively detectable in homozygous B-hCD98HC/Rag2 KO mice (H/H;-/-) but not in WT mice (+/+).
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